Course Details in 2023/24 Session

Module Title	Cellular Biochemistry and Biology
School	Cancer Studies
Department	Inst of Cancer / Genomic Sci
Module Code	02 27065
Module Lead	Andrew Turnell / Chris Weston (deputy)
Level	Certificate Level
Credits	20
Semester	Semester 1
Pre-requisites
Co-requisites
Restrictions	Compulsory module for all students registered on 1710 year 1 It is a requirement that students achieve a mark of at least 35% in their summative exam
Exclusions
Description	The aim of this module is to provide a basic understanding of protein biochemistry and build from this to provide an overview of the key processes in cell biology. Description of the fundamental elements of protein structure and function will be taught alongside the relevant chemical and physical science principles to provide a context for understanding the basic quantitative elements of biochemistry and an appreciation of how proteins are studied and the applications for proteins in biomedicine. This will provide the student with sufficient background to understand the second phase of the module, where the fundamental elements of the cell will be discussed, including cell structure, motility, adhesion, signalling, proliferation, trafficking and regulation.
Learning Outcomes	By the end of the module students should be able to: Describe the principle of chemical ionisation and apply this knowledge quantitatively in the context of pH, buffers and protein action; Give an overview of protein structure, including its origin during biosynthesis, the forces responsible for its maintenance and its relevance to macromolecular assembly and protein substrate interaction, and to apply this in the context of structure/function relationships; Describe the basic aspects of enzyme kinetics and its analysis and apply this knowledge to interpret a simple experimental data set; Describe the basis of the key methodologies used to purify and analyse proteins and use this information to design a simple preparative or analytical process; Describe the underlying structure of the cell and the contributions of the cytoskeleton, cell adhesion and membrane compartments to cell function; Describe the basic strategies used by cells to communicate and how this influences cell proliferation and to apply this knowledge to design experimental outlines to investigate its consequences; Describe key intracellular trafficking events used to transport cargoes between compartments of the cell and the relationship of these processes to the activation and degradation of proteins.
Assessment	27065-01 : Overall module mark : Mixed (100%)
Assessment Methods & Exceptions	Assessments: Module assessment will comprise a combination of a written unseen paper and in-course assessments: 1) Examination (2 hours; MCQs and SAQs): 50% 2) In course assessment 50%: Students will give individual 10 minute oral presentations, each covering a specified aspect of the module (25%) and a January MCQ (50 questions, 1 hour, 25%). Reassessment: Academic failure: If a student fails the module then they will be required to repeat the failed components only. Failure to submit: Submission of coursework is compulsory for the programme. Students are advised that failure to submit without justifiable reason could result in failure of the module. Students will be required to submit outstanding work to meet the module outcomes.
Other	75% Inst Cancer & Genomic Sci 25% Inst Immunology & Immunotherapy
Reading List	Essential Cell Biology, Alberts et al (2013) 4th edition, Garland Science ISBN 9780815344551; Molecular Biology of the Cell, Alberts et al (2007) 5th edition Garland Science ISBN 978-0-8153-4106-2; Biochemistry, Berg, Tymoczko and Stryer (2011) W H Freeman, ISBN 9781429229364;