Course Details in 2023/24 Session

Module Title	LC Fundamentals of life science
School	Institute of Clinical Sciences
Department	Biomedical Sciences
Module Code	02 27070
Module Lead	Dr Peter Hewett, Dr Laura O’Neill
Level	Certificate Level
Credits	20
Semester	Semester 1
Pre-requisites
Co-requisites
Restrictions	It is a requirement that students achieve a mark of at least 35% in their summative exam
Contact Hours	Lecture-26 hours Tutorial-6 hours Practical Classes and workshops-9 hours Guided independent study-159 hours Total: 200 hours
Exclusions
Description	The module introduces basic concepts in biomedical sciences and provides a sound knowledge base for subsequent cellular and systems-based modules. It comprises a series of lectures, small group sessions and laboratory-based practical sessions that will lead to an in-depth understanding of some fundamental principles of human biology. The structure and function of DNA, RNA, proteins and lipids are introduced at the beginning of the module. Epigenetics, chromatin structure and their influence on gene expression, and the physiology of fluid compartments, and the biochemistry of energy generation are also discussed. The principles of biodiversity, natural selection and how organisms are exploited as experimental models, sources of nutrition and for pharmaceutical products are considered. The anatomy of some of the major structures of the body are presented. A basic understanding of the causes and consequences of human genetic variation are provided. A description of the molecular methods for investigating pathological genetic variation in man will provide the student with sufficient background to be able to understand the approaches used to investigate the molecular pathology of human disorders
Learning Outcomes	By the end of the module, students should be able to: Demonstrate an understanding of the structure of DNA, RNA, proteins and lipids, and the mechanisms of DNA replication, transcription and translation. Recognise the influence of epigenetics and chromatin structure on gene regulation. Demonstrate an understanding of the fundamental principles of physiology including the role of cell membranes, fluid compartments and maintenance of cell composition and volume. Describe the key biochemical pathways including glycolysis, gluconeogenesis, and oxidative phosphorylation by which energy is generated in the cell. Discuss the principles of evolution, natural selection and biodiversity, and the interactions between humans and other organisms Demonstrate an understanding of human anatomy and histology including the structure and function of epithelium connective tissues, muscle and skin. Describe the basis of germline genetic variation in man and the patterns of Mendelian inheritance Demonstrate an understanding of human genetic disorders arising from gene and chromosomal mutations and their consequences for the individual.
Assessment	27070-01 : Overall module mark : Mixed (100%)
Assessment Methods & Exceptions	Assessments: The module is assessed by a combination of written examination (2 hours comprising MCQ and SAQ questions) and course work. Written examination 50% Course work 50% The course work component will comprise: Essay (1500 words excluding references) Failure to submit: Submission of coursework is compulsory for the programme. Students are advised that failure to submit without justifiable reason could result in failure of the module. Students will be required to submit outstanding work to meet the module outcomes.
Other	None
Reading List