Course Details in 2023/24 Session

Module Title	Vascular Biology and Haematology
School	Inst of Cardiovascular Science
Department	Inst of Card Sciences
Module Code	02 27793
Module Lead	Dr Steve Thomas
Level	Intermediate Level
Credits	10
Semester	Semester 2
Pre-requisites
Co-requisites
Restrictions	None
Contact Hours	Lecture-15 hours Tutorial-5 hours Practical Classes and workshops-3 hours Guided independent study-77 hours Total: 100 hours
Exclusions
Description	The aim of this module is to review both fundamental and clinical aspects of haemostasiology, vascular biology and haematology. The first part of the module will focus on basic aspects of thrombosis, haemostasis and angiogenesis. In particular, the following areas will be covered: haematopoiesis, blood cells, haemostasis, endothelial biology, rheology/haemodynamics, nervous control of blood flow and pharmacology. The second part of the module will then be devoted to both hereditary and acquired haematological diseases. In particular, red blood cell diseases and haemato-oncological pathologies will be explored. The combination of fundamental aspects and clinical implications will allow better understanding the mechanisms and therapeutic approaches to the diseases. The module will explore these concepts through a combination of lectures, small group tutorials, and a laboratory practical session. Sessions in this module will build upon the core concepts of blood composition and vessel structure, introduced in the BMedSc Cardiovascular Sciences module for the first year. This provides a solid grounding in haemostasiology and haematology from which the student will develop through Years 2-3. Therefore, in planning this module, Steve Thomas and Manoj Raghavan have met with year 1 and year 3 cardiovascular module co-ordinators to ensure that this occurs.
Learning Outcomes	By the end of the module students should be able to: Describe basic principles of vascular biology and haematology. Understand the formation of the various blood cells and the role of the bone marrow environment in this process. Describe the normal functions of the red and white blood cells. Describe basic mechanisms of haemostasis and thrombosis and explain differences between conditions and mechanisms of thrombus formation in arteries and veins. Describe endothelial cell structure and function and relate them to mechanisms of angiogenesis. Understand the nervous control of blood flow and local control of endothelial regulation. Understand how red blood cell dysfunction can lead to clinical conditions such as anaemia. Describe the molecular and cellular pathogenesis of clonal haematological diseases, i.e. acute leukaemia, lymphoproliferative diseases and myeloproliferative diseases. Relate clinical features of haematological diseases and appraise treatments used. Interpret clinically relevant data and use their knowledge to compose possible reasons for their observations.
Assessment	27793-01 : Overall Module Mark : Mixed (100%)
Assessment Methods & Exceptions	Assessments: Examination 50% In-course assessment 50% (1) Final exam (1hr) to include: - 4 short answer questions - 1 essay (2) In course assessment - student presentation Reassessment: Academic failure: If a student fails the module then they will be required to repeat the failed components only. Failure to submit: Submission of coursework is compulsory for the programme. Students are advised that failure to submit without justifiable reason could result in failure of the module. Students will be required to submit outstanding work to meet the module outcomes.
Other	None
Reading List	Essential Haematology (6th ed. 2011) Hoffbrand, Petit, Moss; Medical Physiology (4th ed. 2013) Rhoades and Bell; Molecular Biology of the Cell (4th ed. 2002) Alberts et al; Molecular Haematology (3rd ed. 2010) Petit and Gribben;