Course Details in 2025/26 Session

Module Title	LH From Genes to Therapy
School	Cancer Studies
Department	Inst of Cancer / Genomic Sci
Module Code	02 33892
Module Lead	Dr Maarten Hoogenkamp & Dr. Richard Tuxworth
Level	Honours Level
Credits	40
Semester	Semester 1
Pre-requisites
Co-requisites
Restrictions	It is a requirement that students achieve a mark of at least 35% in their summative exam
Contact Hours	Lecture-22 hours Tutorial-11 hours Practical Classes and workshops-26 hours Guided independent study-341 hours Total: 400 hours
Exclusions
Description	The aim of this course is to provide informed answers to the commonly asked questions: how do genes shape our appearance, behaviour and health? How can we investigate the genetic basis of disease? How can genetics help in tailoring new therapies and developing personalized medicine? How will the availability of our own genome sequences affect our lives?
Learning Outcomes	By the end of the module, students should be able to: Demonstrate a detailed understanding of the principles and methodology involved in the cloning of human disease genes including the use of computerised data bases Outline the methodology and application of advanced cytogenetic techniques Construct and evaluate simple pedigrees Demonstrate a critical understanding of current research on gene control and how it can be altered including the relationship between the structure and function of genes and how mutation can affect this relationship Demonstrate an understanding of concepts such as gain of function, and loss of function with respect to human disease and/or how these can be related to epigenetic phenomena Demonstrate a critical awareness of some of the complex issues involved in genetic counselling Demonstrate an understanding of linkage and the concept of LOD scores Demonstrate an understanding of simple gene expression analysis experiments, and be able to apply this in interpreting experimental data Demonstrate a critical understanding of the genome-wide methodologies applied to annotate functional elements of the genome and/or to detect variants that affect coding and non-coding function.
Assessment	33892-01 : Overall module mark : Mixed (100%)
Assessment Methods & Exceptions	The module is assessed by a combination of a 3 hour written examination (50%) and course work (50%) - experimental data interpretation - practical write up Reassessment: Academic failure: If a student fails the module then they will be required to repeat the failed components only. Failure to submit: Submission of coursework is compulsory for the programme. Students are advised that failure to submit without justifiable reason could result in failure of the module. Students will be required to submit outstanding work to meet the module outcomes.
Other
Reading List