The module will build on basic knowledge provided in previous modules with a focus on the application of immunotherapy in the treatment of disease.
The module will define the role of small molecules and biological therapies in the management of autoimmune disease, with specific emphasis on rheumatoid arthritis, Sjogren’s syndrome and SLE. The pathogenesis of these conditions will be discussed in the context of identifying drug targets. The results of clinical studies will be interpreted in order to gain deeper understanding of disease mechanisms and practical aspects of clinical trial design.
Students will also be exposed to emerging novel therapeutic approaches to the treatment of disease including cellular therapies and modulation of the host (e.g. by diet).
Students will also be guided through the process of writing a description of a piece of research with the aim of communicating the major concepts or conclusions to a lay audience.
The module will contain a combination of face-to-face lectures integrated with a series of small group teaching sessions to provide further tuition and clarification of understanding.
Learning Outcomes
By the end of the module students should be able to:
Describe the pathogenesis of a number of autoimmune diseases in relation to the identification of immunomodulatory therapeutic targets;
Appreciate the complexities of conducting clinical studies in autoimmune disease;
Understand how the results of clinical studies of immunotherapies can contribute to the understanding of disease;
Describe the role of small molecule inhibitors and biological drugs in the management of disease;
Be able to describe novel approaches to immunotherapy including cellular therapies, antigen-specific immunotherapy and dietary modulation;
Demonstrate the ability to effectively communicate the complex scientific concepts of immunotherapy for a lay audience.
Coursework (50%): A description of a piece of research (-plain English summary-) with the aim of communicating the major concepts or conclusions to a lay audience, including a summary of the relevant underlying disease pathogenesis. (2000 words)
Reassessment: If a student fails the module then they will be required to repeat the failed components only.
