The success or failure of biomaterials depends on many factors, not least the interactions with tissues, cells and microbes. This module will include the following topics: Introduction/revision to eukaryotic cells relevant in the oral cavity Introduction/revision to bacteria relevant in the oral cavity Overview of cell and tissue interactions with both conventional and novel materials, including surface texturing and coating Tissue regeneration, cytotoxicity, wound healing Antibacterial strategies Interplay of cells and microbes Testing and Manufacturing of materials, including in vitro and in vivo testing, sterile manufacturing
Learning Outcomes
By the end of the module students should be able to:
Describe the characteristics of relevant eukaryotic cells in the oral cavity and demonstrate an understanding of the processes of tissue regeneration
Develop an understanding of the processes of inflammation and wound healing.
Define appropriate terms for biocompatibility and bio-functionality and apply their meaning to the use of dental materials in the oral cavity.
Demonstrate an understanding of the key oral bacteria in health and disease, including biofilm formation and possible disruption.
Demonstrate an understanding of a variety of antimicrobial strategies, including antibiotics, natural substances and a variety of textured or coated materials.
Demonstrate a critical awareness of materials testing and manufacturing, including in vitro tests, in vivo tests, clinical trials and sterile manufacturing.
Assessments: The module will be assessed by: 1.5 hour written exam (50%) graph and detailed legend based on the cell culture practical (15%) 3. a 2000-word practical report on the bacteriology practical (35%)
Reassessment:
Repeat examination of failed components only. If reassessment of the ICAs is required, an individual 1000-word essay on a topic similar to the initial assignment will be set.
Internal hurdles:
An overall mark of 50% or above must be obtained to pass the module, with each individual assessment scoring not less than 40%.
