Course Details in

Module Title	LH Cellular Neurobiology
School	School of Bioscience
Department	School of Biosciences
Module Code	03 14675
Module Lead	Carolina Rezaval
Level	Honours Level
Credits	20
Semester	Semester 1
Pre-requisites	LI Topics in Medical Biosciences - (03 18540) LI Animal Biology: Principles and Mechanisms - (03 28822)
Co-requisites
Restrictions	None
Contact Hours	Lecture-21 hours Tutorial-10 hours Practical Classes and workshops-3 hours Guided independent study-166 hours Total: 200 hours
Exclusions
Description	This module examines current progress on the understanding of central nervous system development and function, based upon the exploitation of anatomical, genetic, molecular, and advanced physiological techniques. The physiology and molecular biology of neurons is examined. Topics covered are likely to include: how neurons work; synaptic transmission and plasticity, and the techniques to record it; how the brain works; how all the above are grounded on nervous system development. We will pay particular attention to cellular, genetic, and molecular mechanisms. Most if not all mechanisms that give rise to the nervous system are conserved in all animals, but they were often discovered using model organisms. Thus, we will compare findings from models such as the fruit-fly Drosophila, the worm C.elegans and vertebrate models like birds and rodents. These mechanisms may include generation of cell type diversity (neurons, glia), regulation of growth and cell number, emergence and structure of neural circuits and topographic mapping in the brain, synapse formation and elimination, how the brain changes throughout life, learning and memory. Structure enables brain function, which in turn influences brain structure. Thus, we will look at how the principles of development help understand brain plasticity and degeneration and unravel cutting edge approaches to nervous system regeneration. Throughout these topics, we will look at how technological innovation has driven progress, and will explore cutting-edge techniques, which may include optogenetics to stimulate neurons with light, connectomics to decode neural circuits and stem cell transplantations for regeneration.
Learning Outcomes	By the end of the module, students should be able to: Understand and explain the mechanisms of synaptic transmission and synaptic plasticity and techniques for study of nerve cell function Understand and explain the cellular and genetic bases of neural circuits and how they drive behaviour. Understand and explain the fundamental principles of cognition. Understand and explain the genetic, molecular and cellular mechanisms of nervous system development, plasticity and regeneration. Present scientific data (written, figures and tables) Assess and evaluate primary information from the scientific literature and make evidence-grounded decisions on scientific work
Assessment	14675-03 : Referee Report : Coursework (50%) 14675-05 : Examination : Exam (Centrally timetabled) - Computer based (50%)
Assessment Methods & Exceptions	Assessment: Examination: (50%); In-course assessment (scientific report; 50%) Reassessment: Reassessment is via an examination in the supplementary exam period (100% of the module).
Other	None
Reading List