Programme And Module Handbook
Course Details in 2027/28 Session

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Module Title LM Synthesis of Natural Products
Department Chemistry
Module Code 03 20494
Module Lead Dr Richard Grainger
Level Masters Level
Credits 10
Semester Semester 2
Restrictions The module is available to all students on the above programmes and is offered to suitably qualified occasional students. For the latter, enrolment is determined on a case-by-case basis using academic transcripts.
Contact Hours Lecture-11 hours
Practical Classes and workshops-14 hours
Guided independent study-75 hours
Total: 100 hours

The potential biological applications of many natural products provide one very important reason for tackling their synthesis, and rising to the challenge of developing an elegant and creative approach to the preparation of complex molecules is perhaps more of a driving force than synthetic chemists would dare admit! This course discusses some of the issues that arise when devising a total synthesis, and outlines some of the strategies which have been used to realise the total synthesis of complex natural products. The course builds on lecture material delivered earlier in the programme.

Learning Outcomes By the end of the module students should be able to:
  • apply the important concepts used in modern approaches to natural product synthesis;
  • recognise and address chemo-, regio- and stereoselectivity issues for key transformations;
  • Demonstrate an ability to work independently, i.e. adopt student-centred study modes;
  • analyse a complex natural product and propose logical and strategic bond disconnections;
  • use a range of protecting groups in the synthesis of complex targets;
  • understand how tandem reactions can be utilised for the synthesis of polycyclic molecules;
  • identify fortuitous symmetry elements in target molecules and exploit them to simplify synthetic routes;
  • understand how enzymes can be exploited to provide control in the manipulation of polyfunctional molecules;
Assessment 20494-01 : Module Assessment : Exam (School Arranged) - Written Unseen (100%)
Assessment Methods & Exceptions Worksheets (20%) and exam (80%)
Other None
Reading List