Course Details in 2024/25 Session

Module Title	LM Metals in Action: Light Activated Supramolecules and Bioinorganic Chemistry
School	Chemistry
Department	Chemistry
Module Code	03 37556
Module Lead	Prof. Mike Hannon
Level	Masters Level
Credits	10
Semester	Semester 2
Pre-requisites
Co-requisites
Restrictions	None
Contact Hours	Lecture-16 hours Guided independent study-84 hours Total: 100 hours
Exclusions
Description	This module is composed of two components. The first part aims to present the significance of metal complexes in the design of supramolecular structures with targeted photophysical properties which control the function. Evaluation and comparison of the properties of metal probes in comparison with organic and nanomolecular probes. The photophysical/photochemical properties involved in metal based-solar energy conversion systems, design of molecular wires, luminescent probes for sensing and biological imaging will be analysed. Important learning outcomes of the course are the importance of light activated metals and how to select the metal probes in multi–component assemblies to achieve a sophisticated system that can perform functions not realised by simple molecular units. In the second component of the module, the importance of metal ions in biology and their relative abundance in the body will be explored. The topics to be covered include: hydrolytic enzymes; metallo-proteins and metallo-enzymes; up-take and storage; and elements in medicine.
Learning Outcomes	By the end of the module students should be able to: Discuss photophysical properties of organic and inorganic fluorescent molecules used as probes. Compare photophysical processes in inorganic and organic systems Outline experimental evidence for demonstration of energy and electron transfer pathways. Describe the photophysical processes of the natural photosynthetic system and apply known molecular building block for the design of an artificial photosynthetic system. Design molecular and nanomolecular systems that act as wires. Predict requirements for constructing solar energy conversion systems. Propose applications of luminescent labels and sensors. Understand which metals are used in biology and why, and predict the roles they can play. Understand the roles of metals in hydrolytic enzymes and predict properties. Understand the roles of metals and ligands in therapy in the clinic and their clinical drawbacks, and use this knowledge to propose new drugs that might be suitable for future research. Understand how molecules can bind to DNA and affect their structure, and use this knowledge to predict DNA binding of unseen agents. Understand how biological systems regulate the uptake of metals and how they are stored in the body and why this is important. Understand why electron transfer is crucial in biology and why metals are key to this.
Assessment	37556-01 : Module Assessment : Exam (School Arranged) - Written Unseen (100%)
Assessment Methods & Exceptions	Class tests
Other
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