Programme And Module Handbook
 
Course Details in 2021/22 Session


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Module Title Bioseparations
SchoolChemical Engineering
Department Chemical Engineering
Module Code 04 19768
Module Lead Prof. Owen Thomas
Level Masters Level
Credits 20
Semester Semester 2
Pre-requisites
Co-requisites
Restrictions None
Exclusions
Description The following topics are covered in the module:
General downstream processing, Recombinant protein hosts, Cell disruption strategies, Aggregation, Fractional precipitation, Centrifugation and centrifuges, Conventional filtration, Membrane separations. Introduction to process chromatography.
Principles and theories of chromatography, Chromatography: adsorption & adsorption models; resolution & zone broadening; three phase strategies & linking steps; process development; development of media; scale-up & optimisation.
Alternatives to chromatography including Expanded bed adsorption & Magnetic separations.
Learning Outcomes By the end of the module the student should be able to:
  • Demonstrate comprehensive understanding of the practices employed in the recovery of industrially important molecules typically produced by fermentation;
  • Systematically design detailed downstream process design flow sheets for any bioproduct when supplied with relatively little information concerning, e.g. the intended use, amount required, the host, and some characteristics of the product;
  • Select the appropriate equipment, chromatographic materials and process chemicals for each of the various stages in a downstream process.
Assessment 19768-01 : Online Class Test : Class Test (50%)
19768-03 : Coursework : Coursework (50%)
Assessment Methods & Exceptions 50% online class tests (Canvas), 50% written coursework (Canvas). Reassessment: 100% coursework (Canvas).
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