If you find any data displayed on this website that should be amended, please contact the Curriculum Management Team.
Module Title
Bioseparations
School
Chemical Engineering
Department
Chemical Engineering
Module Code
04 19768
Module Lead
Prof. Owen Thomas
Level
Masters Level
Credits
20
Semester
Semester 2
Pre-requisites
Co-requisites
Restrictions
None
Exclusions
Description
The following topics are covered in the module: General downstream processing, Recombinant protein hosts, Cell disruption strategies, Aggregation, Fractional precipitation, Centrifugation and centrifuges, Conventional filtration, Membrane separations. Introduction to process chromatography. Principles and theories of chromatography, Chromatography: adsorption & adsorption models; resolution & zone broadening; three phase strategies & linking steps; process development; development of media; scale-up & optimisation. Alternatives to chromatography including Expanded bed adsorption & Magnetic separations.
Learning Outcomes
By the end of the module the student should be able to:
Demonstrate comprehensive understanding of the practices employed in the recovery of industrially important molecules typically produced by fermentation;
Systematically design detailed downstream process design flow sheets for any bioproduct when supplied with relatively little information concerning, e.g. the intended use, amount required, the host, and some characteristics of the product;
Select the appropriate equipment, chromatographic materials and process chemicals for each of the various stages in a downstream process.
